Although roselle has well documented hypotensive effects, Hibiscus has one of the highest levels of antioxidants of any widely available food; antioxidants have been shown in several studies to enhance nitric oxide production in the body, reducing blood pressure and oxidized lipids. Antioxidants have also reduced cancer promotion in several studies, and plants containing large amounts of antioxidants are regularly studied for their known anti-cancer effects, and promotion of good health by enabling oxidative balance.
The hypotensive effect of roselle drink does not seem to be attributable to a possible diuretic effect, for which no evidence was found in an experimental study.
A double blind, placebo controlled, randomized trial was conducted to determine the effect of roselle leaf extract on a group of 60 subjects with serum LDL values in the range of 130-190 ml/dl (<130 ml/dl is a goal value for most patients) and no history of coronary heart disease. The experimental group received 1g of roselle leaf extract while the placebo group received a similar amount of maltodextrin in addition to dietary and physical activity advice. Both groups had decreases in body weight, LDL cholesterol, and triglycerides that can likely be attributed to the dietary and physical activity advice. At a dose of 1g/day, roselle leaf extract did not appear to have a blood lipid lowering effect.
Hibiscus sabdariffa has shown in vitro antimicrobial activity against E. coli. A recent review stated that specific extracts ofH. sabdariffa exhibit activities against atherosclerosis, liver disease, cancer, diabetes and other metabolic syndromes.
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